Cardarine GW 501516 SARM Review

Cardarine GW 501516 is another compound that is commonly perceived to be a SARM. In this Cardarine GW 501516 Review, you will find out what this compound, in reality, is, how it works, why it is used by bodybuilders, what its benefits and side effects are, and what the legal status of this compound is.

Cardarine GW 501516 Review

Let’s check out more about Cardarine…

Cardarine GW 501516 SARM Review

What is Cardarine GW 501516?

Cardarine GW 501516 is commonly spoken of in the same breath as a SARM because of its anabolic and fat-burning properties but in fact, it is a PPARD or Peroxisome Proliferator-Activated Receptor Delta.

Cardarine first came into inception in the year 1992 and is still subject to research and trials. You must keep in mind that it has not been approved for human consumption by the FDA till now.

Early results have shown that Cardarine can be effective in changing body composition and can help improve athletic performance too. This is why it has been banned by most athletic bodies including WADA (since it is likely to give an unfair advantage to the user over other competitors.

One of the most important benefits of Cardarine SARM is that it is known to help boost fat burning in your body. This has made it a promising aid for the treatment of obesity and has made it quite lucrative to bodybuilders and weightlifters who want to lose fat while retaining muscle mass during the cutting cycles.

Is Cardarine Legal?

Let me put it straight – Cardarine is not approved by the FDA for human consumption and as such, it is not legal to buy for bodybuilding or professional use. I must also mention here that FDA has concerns over it having carcinogenic effects and that’s why it has not been approved yet.

Secondly, it falls on the list of banned substances by WADA. Its use in professional sports is prohibited since it can help the user get an unfair advantage over other athletes.

Having said that, it is legal to buy for research purposes. Most bodybuilders and gymgoers take advantage of this loophole to buy Cardarine.

Cardarine GW 501516 SARM review

Cardarine Benefits

Some of the main benefits of Cardarine are listed below:

Fat Loss

One of the most important and significant benefits of Cardarine is that it bears a positive impact on insulin sensitivity, lipid balance, as well as glucose tolerance, and thus it is able to enhance lipolysis.

It tends to shift the source of energy for your body from glucose to fat oxidization. In other words, it helps burn your body’s fat reserves in order to meet its energy demands.

What is important to know is that it helps reduce body subcutaneous as well as visceral fat in your body, giving you a leaner and more defined appearance.

One of the most apparent signs of reduced visceral fat is a reduction in your waist size. Excess visceral fat often leads to a protruding stomach or a bulging waistline and trimming this fat helps trim your waist.

Another SARM that has similar lipolytic effects is Ostarine MK 2866.

Moreover, anecdotal evidence shows that as far as Cardarine is concerned, its fat-burning effects are more pronounced as compared to its muscle-building effects. Thus, it is a compound that can be used for a cutting cycle more effectively.

Another important fact is that since Cardarine has a positive effect on Insulin and blood glucose levels, it might be a potential treatment for type II diabetes in the future.

Muscle Hypertrophy

Another interestinf fact about Cardarine is that it can produce simultaneous anabolic effects. What it means is that it can hep increase lean muscle too. According to a study, subjects are known to have experienced an increase in lean muscle mass by 1.3 kg with a dosage of 10mg/day for a period of 12 weeks.

However, I must say that this increase in muscle mass does not get anywhere close to what you can experience with the help of anabolic steroids or even other SARMs such as RAD 140 or LGD 4033.

Muscle Endurance

Yet another important benefit of Cardarine is that it can produce a dramatic effect on muscular endurance. Through mitochondrial biogenesis, Cardarine helps convert fast twitch fibers into slow twitch which helps you delay fatigue so that you can train harder and longer.

What you need to understand is that slow twitch fibers can help your body utilize oxygen more efficiently thereby enabling higher levels of ATP production inside the muscle cells.

According to a study on mice, Cardarine is known to have increased endurance by as much as 68% in just a period of 3 weeks.

Cardarine is so effective for enhancing endurance that if you were able to do cardio for 30 minutes before having it, you should be able to do cardio for as much as 50 minutes before reaching the same level of exhaustion.

Furthermore, it is important to understand that better endurance can indirectly help you burn stored fat faster particularly when combined with an intense training routine, whether cardio or strength workout.

Though these Cardarine effects of enhanced endurance are only temporary and last only as long as you keep taking Cardarine, users are likely to experience better endurance long after you stop taking Cardarine because of muscle memory. (It’s worth knowing that your heart is a muscle!)

Another important factor that affects your endurance levels post Cardarine cycle is whether you continue training or not. If you stop training post Cardarine cycle, your endurance levels are likely to drop faster.

Glycogen Storage

Another important benefit is that Cardarine GW 501516 can help increase glycogen storage inside your muscles, making them look fuller. This is a great feature of bodybuilders as well as fitness models who want their muscles to look full and bigger on stage and are prone to experience glycogen depletion because of calorie-restrictive diets.

Not just this, Cardarine is also likely to reduce levels of extracellular fluid and this may help boost your vascularity.

Improved Cholesterol

Cardarine is also known to be good for your cardiac health. It is known to have a positive impact on your HDL cholesterol which is good cholesterol.

You must keep in mind that this is a unique benefit of Cardarine since most anabolic steroids and SARM actually lower HDL cholesterol and affect your lipid profile negatively.

In the study mentioned, above, it was observed that a 10mg/day dosage increased HDL cholesterol by as much as 17% while decreasing LDL cholesterol by as much as 7%.

This is one of the major reasons why most bodybuilders prefer stacking Cardarine with anabolic steroids and SARMs so that they may just not be able to improve their body composition and performance but also reduce the risk of cardiac issues.

This is one benefit that makes it a perfect potential treatment for dyslipidemia in the future.

Does Not Suppress Testosterone

One of the most common complications arising out of the use of anabolic steroids and SARMs is that they can reduced endogenous testosterone levels in your body largely because of overstimulation of the androgen receptor (thereby requiring you to opt for PCT so as to get your testosterone levels back to normal).

However Cardarine, as mentioned above, is a PPARD that does not affect HPT or your hypothalamic-pituitary-testicular axis. In simple words, Cardarine does not affect your testosterone levels.

No Virilization Effects In Women

Cardarine is a compound that can be used by women too. What sets it apart from most anabolic steroids and SARMs is that it does lead to virilization or development of male characteristics in women.

So, if you want to get rid of layers of subcutaneous fat in your body and still retain all your feminine characteristics, Cardarine may be the best choice available for you.

The main reason behind this is that Cardarine does not affect your hormones, more specifically testosterone. Thus, women are not likely to experience any deepening of the voice, clitoral enlargement, irregular periods, breast reduction, etc., when taking this compound.

Does it mean Cardarine is safe for women to use?

Not necessarily!

Even though Cardarine does not cause virilization in women, it does not mean that is safe for them. This is because it is still subject to research and study (not all the long-term and short-term side effects of this compound are completely known as of now).

In contrast, Anavar is known to be a better alternative since it is an approved FDA medicine for various conditions in women and children.

Anavar has low virilization effects in women when taken in conservative dosages. Thus, it is considered safer as compared to Cardarine (for fat loss) with its effects being well-known and studied over a longer period of time.

Cardarine Side Effects

Let’s check out some of the side effects of Cardarine…

Cardarine GW 501516 SARM Review


One of the complications seen in long-term trials that led to Cardarine being withdrawn from further development in 2009 was that it produced cancer in all dosages. It was known to have caused tumors of all kinds that included those of the thyroid, liver, bladder, stomach, skin, tongue, uterus, eyes, and even tested.

Having said that, it is important to highlight the fact that during such trials excessive dosages were used for a long period of time. The lowest dosage that was given to rodents was 5mg/kg per day and it translated as 65mg/day for an 80 kg human, which also resulted in the development of cancer.

It is worth mentioning here that heavy dosage of Cardarine was given to rodents in a study for an extended 2-year cycle which obviously, is quite excessive and that most gym-goers or bodybuilders are likely to use it for a cycle lasting 8 weeks.

Liver Toxicity

Cardarine is known to have caused significant fluctuations in ALT and AST liver enzymes during trials with dosages up to 10 mg/ day.

It is interesting to note that Cardarine can cause liver toxicity that is equivalent to having 50 mg/ day of Anavar, which is a very high dosage.

One of the major effects of Cardarine is that it can cause cellular proliferation. In other words, it stimulates cell growth and division, thereby increasing the overall cell count. Now, this could be fine in a normally healthy person but in the case of a person with an existing hepatic injury, this can speed up the death of liver cells.

Since Cardarine is often used by bodybuilders and other individuals who have already taken SARMs or anabolic steroids (in other words, people who have a history of using hepatotoxic compounds) this can lead to hepatic complications.

Moreover, it is important to note that even anti-depressants and alcohol can be a dangerous combination with Cardarine.

Thus, anyone planning to include Cardarine into his supplement regime must have his liver enzymes tested to get a clear idea of his liver health before potential cellular proliferation takes place.


According to anecdotal evidence, Cardarine is known to result in insomnia in some people, which indicates that it has a stimulating effect on the central nervous system and that it also increases the adrenaline output.

However, this is something that can be tackled by altering the time of taking your dosage. If you take your Cardarine dosage earlier in the day or in the morning then you should be able to sleep properly.

Even though Cardarine is known to stimulate the CNS or central nervous system, this is not likely to e excessive as it is in the case of Clenbuterol. It does not make you jittery such as some of the most powerful thermogenic fat burners. On the contrary, Cardarine ensures your energy levels are quite stable (there are no crashes) and it also improves overall well-being.

Cardarine Results – Before and After Pictures

Here are some before and after pics of Cardarine users:

Caradine Results #1

Cardarine GW 501516 Review

This is a classic example of complete body transformation with Cardarine and LGD 4033. Cardarine obviously has been used for cutting while LGD 4033 Ligandrol has helped him gain at least 8-10 pounds of muscle mass.

Results like this are attainable when you combine Cardarine and LGD 4033 with a proper training regime and a proper diet. Another very important factor to keep in mind is that you must be able to procure pure compounds. Bunk products not only make such results unattainable but also lead to unwanted and sometimes, dangerous side effects.

Cardarine Results #2

This guy has combined Cardarine GW 501516 with an intense training routine and a proper diet to achieve excellent cutting results. He has been able to knock off 20 lbs of weight and lose around 5% body fat. He is known to have taken 10mg of Cardarine per day for a 4-week cycle.

Apart from the cutting results that are evident from the pics above, he has also been able to improve his cardiovascular performance during this Cardarine cycle.

Cardarine Dosage

Since Cardarine GW 501516 has not been approved by the FDA for either medicinal purposes or for bodybuilding, there are no clear instructions with regards to Cardarine dosage.

Having said that, most users take Cardarine within the range of 10-20mg/day. More often than not, a single dose is taken in a day, preferably 30 minutes before the workout. This is to ensure better fat burning or oxidization during the workout.

Cardarine Cycle

Generally, bodybuilders opt for a Cardarine cycle that lasts 6-12 weeks and the most common dosage varies between 10-20mg/day.

As shown in the before and after pics above (Cardarine results #2) lower dosage within the range of 10-20mg/day for a shorter cycle (4 weeks) can help you get an amazing transformation.

Besides this, you must keep in mind that a higher dosage/longer cycle increases the risk of developing cancer.

Ostarine and Cardarine Stack

Even though most users use Cardarine as a standalone product for a cutting cycle, it can be combined with Ostarine MK 2866 for even better fat loss results.

Following is a what a typical Cardarine and Ostarine cycle looks like:

1-820 mg/day20 mg/day

Ostarine is usually thought of as a cutting SARM since its fat-burning effects are more pronounced as compared to muscle-building effects.

However, this is a compound that is also known to lower HDL cholesterol. It is suppressive too and can lower testosterone levels in your body. Not just this, it can also increase liver toxicity.

What it means is that combining Ostarine with Cardarine is likely to make you experience a whole lot of side effects. Cardarine only cycle is thus a better option.

Should You Stack Cardarine?

As mentioned above, Cardarine can increase cellular proliferation and as such, it may not be safe to stack it with compounds that are harsh on the liver such as SARMs or anabolic steroids.

Stacking Cardarine with anabolic steroids and SARMs may get highly toxic to your liver and elevate ALT/AST enzymes resulting in liver damage.

How To Take Cardarine?

Like most other SARMs, Cardarine also comes in the form of:

  • Liquid solution (20mg/ml)
  • Tablet form (10mg)

You can use a syringe to measure out liquid Cardarine before you actually put it in your mouth to swallow it.

One of the best options to consume it is to have it sublingually. This is going to allow better absorption. All you need to do is put it underneath your tongue and allow it to sit there for 10-15 seconds before you swallow it. This ensures that it comes in direct contact with the muscus membrane and is able to reach the bloodstream directly. This not only ensures better results but also cut shorts the reaction time.

Another important thing to remember is that it is better to plan your workouts earlier in the day, preferably in the morning since Cardarine has a stimulating nature. This will not only help you do your workout better but will also help you wind down your central nervous system by the time you are ready to hit the bed at night.

Safe and Legal Alternative To Cardarine

One of the best ways to get all the benefits of Cardarine GW 501516 without fearing any side effects is by having safe, legal and natural alternative such as C-Dine 501516 from Crazy Bulk.

Crazy Bulk is a well established brand that has been getting awesome user reviews for its range of legal anabolic steroids and SARMs.

C-Dine 501516 is a natural and legal SARM that can help you get amazing results from your workouts whether you want to get ripped and shredded muscles or you are trying to boost your cardio performance.

C-Dine 501516:

  • Torches body fat
  • Helps lose weight faster
  • Burns fat to increase energy
  • Great for enhancing muscle definition
  • Shapes up abs
  • Increases Endurance
  • Has no side effects
  • Does not require a PCT

C=Dine 501516 is a supplement formulated with natural ingredients and it does not have any negative side effects. The beauty of this supplement lies in the fact that you do not require a PCT once you are done with the cycle.

It is recommended that you try it for at least 4-5 months to get the best results. Click on the button below to check out my unbiased and detailed C-Dine 501516 Review.


How long does it take for Cardarine to kick in?

Cardarine kicks in really fast. User report begin feeling the effects just 20 minutes after consuming the first dose.

Is Cardarine a good fat burner?

Cardarine is a powerful fat burner that can help torch excess fat from your body. It is not just used by bodybuilders for a cutting cycle but is also used by athletes to improve their performance and endurance levels.

Can Cardarine build muscle?

Cardarine GW 501516 is a fat burner that can also help you get more defined muscles. It has more pronounced fat-burning effects as compared to muscle-building effects. If you want to gain muscle, you should opt for some other SARM such as RAD 140 or LGD 4033.


Even though Cardarine is assumed to be a SARM it is a PPARD. It is excellent for burning fat and has found extreme popularity amongst bodybuilders and athletes who not only want to lose fat but also want to increase their endurance levels. Though it is safe when used in low dosages and for a short period of time, long-term use can lead to a lot of side effects. It is better to use a natural and safe alternative such as C-Dine 501516 from Crazy Bulk that mimics Cardarine without any of its side effects.

Similar Posts

Leave a Reply

Your email address will not be published. Required fields are marked *